SimuGen’s HT-X™ screening programmes offer comprehensive toxicity testing services and state-of-the-art technology leading to unique insights into the safety profile of your compounds.

A typical programme consists of the following four complementary stages:

Stage 1 - SimuGen consultation: Expert consultation on prior knowledge and expected outcomes – resulting in a toxicity testing roadmap

Stage 2 - HT-Xplore: Preliminary genomics screening using microarrays/qPCR and bioinformatics analysis – resulting in a broad understanding of the compounds’ toxic effects

Stage 3 - HT-Xpress: Combined High Content Screening and Gene Expression Profiling technologies – resulting in unprecedented toxicity pathway insights and physiological effects

Stage 4 - HT-Xpert: Comprehensive dose-response toxicity screens using SimuGen’s quantitative HT-Stream™ software – resulting in predictive dose and potentially structure related analyses

The end product from stages 1 to 4 will be a set of reports giving valuable insights at each stage into various well recognized and accepted aspects of the in vitro toxicity profile of a compound. 

If you would like to know how SimuGen could help with your drug safety screening, then use the button below to request a quote.